青云英语翻译

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以前,我们描述了 hbetac,常见的信令亚基造血和炎症因子,通用汽车-CSF、 白细胞介素-3 和白细胞介素-5 受体活化突变。活化的突变,hbetacFIDelta,就能够赋予在小鼠髓系细胞行 FDC P1,和对主要致力髓祖细胞生长因子独立的扩散。我们用这种活化突变研究慢性细胞因子受体刺激的影响。转基因小鼠制造,携带链接到本构的启动子磷酸甘油酸激酶基因,妇女 1 从派生的 hbetacFIDelta cDNA。转基因表达在几个组织中得到体现和突变体受体的功能活动造血组织中所证实粒细胞巨噬细胞和巨噬细胞集落形成细胞 (菌落 GM 和菌落 M) 的存在没有添加细胞因子。所有的转基因小鼠显示骨髓

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我们以前所述hbetac激活的突变,共同信号分队的受体的造血和煽动性的细胞因子,GM-CSF,IL-3、和IL-5。 激活的变异,hbetacfidelta,是可以将增长的因素-独立的扩散不仅会传染鼠疫脊髓细胞FDC-p1,和关于主要致力于骨髓性感到不解。 我们利用这种激活突变的影响进行研究,长期刺激因子受体。

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